Publications

bioRxiv InPress/Prepress 2025

Hyung-Gyoo Kang, Bryon Upton, Ryan W. Holly, Racheal Upton, Sheetal Mitra, Jean-Hugues Parmentier, Ann F. Mohrbacher, Yong-Mi Kim, Timothy J. Triche, Jon O. Nagy. Targeted Nanoparticles: an Innovative Modality in the Treatment of Cancer (InPress / Prepress) bioRxiv 2025.12.01.691687; doi: https://doi.org/10.64898/2025.12.01.691687

American Association for Cancer Research (AACR) 2025

HyungGyoo Kang, Bryon Upton, Jon Nagy, Jann N. Sarkaria, Timothy J. Triche. Enhancing GBM therapy with tumor-targeted nanoparticles [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025 April 25-30; Chicago, IL.: AACR; 2025. Abstract nr LB183/1 

American Association for Cancer Research (AACR) 2023

HyungGyoo Kang, Bryon Upton, Paul Scott, Mark Lewis, Jon Nagy, Timothy Triche. Targeted nanospheres for the treatment of cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 825.

American Association for Cancer Research (AACR) 2022

HyungGyoo Kang, Jon Nagy, Bryon Upton, Timothy Triche. Superior efficacy of targeted nanoparticle therapy for brain tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 295.

American Association for Cancer Research (AACR) 2021

HyungGyoo Kang, Jon Nagy, Bryon Upton, Racheal Upton, Timothy Triche, Timothy Triche. Targeted NanoSpheres (TNS) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 312.

American Association for Cancer Research (AACR) 2020

Hyunggyoo Kang, Jon Nagy, Timothy Triche. Targeted NanoSpheres (TNS): An effective, non-toxic nano-formulated therapeutic platform for broad use in cancer treatment [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 1717.

American Association for Cancer Research (AACR) 2019

Sheetal A. Mitra, Namritha Ravinder, Veronica Magnon, Jon Nagy, Timothy J. Triche. Genomic editing of EWS-FLI1 and its targets, and its therapeutic potential in treatment of Ewing sarcoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4499.

ACS Publications / Langmuir 2019

Gormley CA, Keenan BJ, Buczek-Thomas JA, Pessoa ACSN, Xu J, Monti F, Tabeling P, Holt RG, Nagy JO, Wong JY. Fibrin-Targeted Polymerized Shell Microbubbles as Potential Theranostic Agents for Surgical Adhesions. Langmuir. 2019 Aug 6;35(31):10061-10067. doi: 10.1021/acs.langmuir.8b03692. Epub 2019 Feb 8. PMID: 30681875; PMCID: PMC6767917.

CSH | Cold Spring Harbor laboratory Symposium (2019)

Sheetal A. Mitra, Veronica Magnon, Hyung Gyoo Kang, Bryon Upton, Jon Nagy, Namritha Ravinder, Timothy J. Triche. Using Crispr-Cas9 technology to study biology and develop therapeutics for treatment of Ewing sarcoma. (2019) CSHL-181-Gene Therapy Session. Genome Engineering: Frontiers of Crispr/Cas. CSHL(2019)181-Gene Therapy Session

Cancer Nanotechnology (Gordon Research Conference) Bridging the Translational Gap in Cancer Nanotechnology (2019)

Hyung Gyoo Kang, Jon O. Nagy, Timothy J. Triche, Bryon Upton, Falguni Dasgupta. Targeted NanoSpheres (TNS): A Novel Therapeutic Platform for Cancer 

Highlights Recent Advances in Pediatric Cancer Research (AACR 2019)

Hyung Gyoo Kang, Jon Nagy, Sheetal Mitra, Triche Triche. Targeted therapy of Ewing’s sarcoma by human anti CD99 targeted hybrid polymerized liposomal nanoparticles (HPLNs) encapsulating anticancer agents. 2875 / 11; AACR (2019); Session PO.TB08.01 – Targets and Therapies in Pediatric Cancer

PLOS One 2018

Miettinen HM, Gripentrog JM, Lord CI, Nagy JO. CD177-mediated nanoparticle targeting of human and mouse neutrophils. PLoS One. 2018 Jul 10;13(7):e0200444. doi: 10.1371/journal.pone.0200444. PMID: 29990379; PMCID: PMC6039027.

American Association for Cancer Research (AACR) 2018

Hyunggyoo Kang, Jon Nagy, Timothy Triche. Targeted anticancer drug delivery to Ewing’s sarcoma using human anti-CD99 targeted hybrid polymerization liposomal nanoparticles [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3705.

ACS Applied Materials & Interfaces (Research Article)

Park YC, Zhang C, Kim S, Mohamedi G, Beigie C, Nagy JO, Holt RG, Cleveland RO, Jeon NL, Wong JY. Microvessels-on-a-Chip to Assess Targeted Ultrasound-Assisted Drug Delivery. ACS Appl Mater Interfaces. 2016 Nov 23;8(46):31541-31549. doi: 10.1021/acsami.6b09071. Epub 2016 Nov 9. PMID: 27781429.

American Association for Cancer Reseach (AACR) 2016 (AACR Mini Symposium)

Hyunggyoo Kang, Jon Nagy, Timothy Trivhe. Targeted therapy of leukemia and Ewing’s sarcoma by human antibody-targeted nanoparticles. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2695.

ACS Publications / Langmuir (Research Article)

Park Y, Pham TA, Beigie C, Cabodi M, Cleveland RO, Nagy JO, Wong JY. Monodisperse Micro-Oil Droplets Stabilized by Polymerizable Phospholipid Coatings as Potential Drug Carriers. Langmuir. 2015 Sep 15;31(36):9762-70. doi: 10.1021/acs.langmuir.5b02747. Epub 2015 Sep 4. PMID: 26303989.

Clinical Cancer Research (Research Article)

Kang MH, Wang J, Makena MR, Lee JS, Paz N, Hall CP, Song MM, Calderon RI, Cruz RE, Hindle A, Ko W, Fitzgerald JB, Drummond DC, Triche TJ, Reynolds CP. Activity of MM-398, nanoliposomal irinotecan (nal-IRI), in Ewing’s family tumor xenografts is associated with high exposure of tumor to drug and high SLFN11 expression. Clin Cancer Res. 2015 Mar 1;21(5):1139-50. doi: 10.1158/1078-0432.CCR-14-1882. PMID: 25733708.

Clinical Cancer Research (Research Article)

Guerzoni C, Fiori V, Terracciano M, Manara MC, Moricoli D, Pasello M, Sciandra M, Nicoletti G, Gellini M, Dominici S, Chiodoni C, Fornasari PM, Lollini PL, Colombo MP, Picci P, Cianfriglia M, Magnani M, Scotlandi K. CD99 triggering in Ewing sarcoma delivers a lethal signal through p53 pathway reactivation and cooperates with doxorubicin. Clin Cancer Res. 2015 Jan 1;21(1):146-56. doi: 10.1158/1078-0432.CCR-14-0492. Epub 2014 Dec 11. PMID: 25501132.

American Association for Cancer Research (2014)

Hyunggyoo Kang, Violette Shahbazian, Amanda Schafenacker, Jon Nagy, Timothy Triche. Development of selective therapy of childhood ALL and Ewing’s sarcoma using targeted-hybrid polymerized liposomal nanoparticles (HPLN). [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5424. doi:10.1158/1538-7445.AM2014-5424

JSR | Journal of Surgical Research

Girgis MD, Federman N, Rochefort MM, McCabe KE, Wu AM, Nagy JO, Denny C, Tomlinson JS. An engineered anti-CA19-9 cys-diabody for positron emission tomography imaging of pancreatic cancer and targeting of polymerized liposomal nanoparticles. J Surg Res. 2013 Nov;185(1):45-55. doi: 10.1016/j.jss.2013.05.095. Epub 2013 Jun 19. PMID: 23827791.

ACS Publications / Langmuir (Research Article)

Park Y, Luce AC, Whitaker RD, Amin B, Cabodi M, Nap RJ, Szleifer I, Cleveland RO, Nagy JO, Wong JY. Tunable diacetylene polymerized shell microbubbles as ultrasound contrast agents. Langmuir. 2012 Feb 28;28(8):3766-72. doi: 10.1021/la204510h. Epub 2012 Feb 14. PMID: 22260537; PMCID: PMC3302155.

Sarcoma (Research Article)

Federman N, Chan J, Nagy JO, Landaw EM, McCabe K, Wu AM, Triche T, Kang H, Liu B, Marks JD, Denny CT. Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor. Sarcoma. 2012;2012:126906. doi: 10.1155/2012/126906. Epub 2012 Sep 11. PMID: 23024593; PMCID: PMC3447386.

Critical Reviews™ in Therapeutic Drug Carrier Systems

Puri A, Loomis K, Smith B, Lee JH, Yavlovich A, Heldman E, Blumenthal R. Lipid-based nanoparticles as pharmaceutical drug carriers: from concepts to clinic. Crit Rev Ther Drug Carrier Syst. 2009;26(6):523-80. doi: 10.1615/critrevtherdrugcarriersyst.v26.i6.10. PMID: 20402623; PMCID: PMC2885142.

Biomaterials (Research Article)

Salvador-Morales C, Zhang L, Langer R, Farokhzad OC. Immunocompatibility properties of lipid-polymer hybrid nanoparticles with heterogeneous surface functional groups. Biomaterials. 2009 Apr;30(12):2231-40. doi: 10.1016/j.biomaterials.2009.01.005. Epub 2009 Jan 23. PMID: 19167749; PMCID: PMC2699891.

Cancer Research (Research Article)

Hu-Lieskovan S, Heidel JD, Bartlett DW, Davis ME, Triche TJ. Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing’s sarcoma. Cancer Res. 2005 Oct 1;65(19):8984-92. doi: 10.1158/0008-5472.CAN-05-0565. PMID: 16204072.

ACS Applied Materials & Interfaces (Research Article)

Park YC, Zhang C, Kim S, Mohamedi G, Beigie C, Nagy JO, Holt RG, Cleveland RO, Jeon NL, Wong JY. Microvessels-on-a-Chip to Assess Targeted Ultrasound-Assisted Drug Delivery. ACS Appl Mater Interfaces. 2016 Nov 23;8(46):31541-31549. doi: 10.1021/acsami.6b09071. Epub 2016 Nov 9. PMID: 27781429.

Applied Immunohistochemistry & Molecular Morphology (Research Article)

Llombart-Bosch A, Navarro S. Immunohistochemical detection of EWS and FLI-1 proteinss in Ewing sarcoma and primitive neuroectodermal tumors: comparative analysis with CD99 (MIC-2) expression. Appl Immunohistochem Mol Morphol. 2001 Sep;9(3):255-60. doi: 10.1097/00129039-200109000-00010. PMID: 11556754.

ACS Applied Materials & Interfaces (Research Article)

Rivory LP, Bowles MR, Robert J, Pond SM. Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by human liver carboxylesterase. Biochem Pharmacol. 1996 Oct 11;52(7):1103-11. doi: 10.1016/0006-2952(96)00457-1. PMID: 8831730.